A facile and highly convergent approach to thiazolo[3,2-a]pyridines via one-pot multicomponent domino reaction under metal-free and solvent-free conditions

Operationally and user-simple a highly efficient one-pot three-component (5 molecules) coupling of α-enolic dithioesters, cysteamine hydrochloride and aldehydes afforded a range of thiazolopyridines in high yields under metal-free and solvent-free conditions. The new domino protocol generated two rings by the concomitant formation of seven multiple bonds (two C–C, three C–N and two C–S) involving a sequence of N,S-acetal formation/double Michael addition/N-cyclization as key steps in a single operation.

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