A convenient synthesis of indoloquinolinones via 3-arylation of indole-2-carboxamides and PIDA-mediated C-N bond formation

A series of substituted indoloquinolinones were readily synthesized, via two steps, from indole-2-carboxylic acid and its derivatives: a 3-arylation of indole-2-carboxamides and a subsequent PIDA-mediated oxidative C-N bond formation. The underpinning strategy involves a Cu(I)-promoted C(sp2)-C(sp2) coupling and a PIDA-mediated oxidative C(sp2)-N coupling.