کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5215148 | 1383218 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A convergent route to substituted azetidines and to Boc-protected 4-aminomethylpyrroles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A convergent route to substituted azetidines and to Boc-protected 4-aminomethylpyrroles A convergent route to substituted azetidines and to Boc-protected 4-aminomethylpyrroles](/preview/png/5215148.png)
چکیده انگلیسی
The radical addition of xanthates to Boc-protected azetine gives adducts, which can be reductively dexanthylated to furnish variously substituted azetidines. In the case of α-xanthyl ketones, treatment of the initial adducts with ammonia or primary amines, furnishes 2,4-disubstituted, 2,3,4-trisubstituted, and polycyclic pyrroles having a protected aminomethyl group at position-4. An unusual ring opening was observed in the case of a cyclobutanone precursor. It also proved possible to add an azetidinyl radical to an indole ring. Most of these products would be very difficult to obtain by more conventional routes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 22, 3 June 2015, Pages 3680-3689
Journal: Tetrahedron - Volume 71, Issue 22, 3 June 2015, Pages 3680-3689
نویسندگان
Songzhe Han, Samir Z. Zard,