Formal total synthesis of (±)-rhazinal and its B-ring carbamate analogue

Rhazinal and its analogues are microtubule and tubulin polymerisation disrupting agents. A formal synthesis of rhazinal is described. An interesting observation from the studies emerged about reposition of the natural product with slight modification in the structure. This opens up new possibilities for older natural products for finding better therapeutics. B-ring carbamate of rhazinal showed AChE inhibitory activity comparable to known reference standard galantamine and no cytotoxicity.