کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5215768 | 1383243 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition](/preview/png/5215768.png)
چکیده انگلیسی
A pair of novel chiral auxiliaries SAMIQ/RAMIQ was synthesized from l- or d-phenylalanine methyl ester hydrochloride over six steps in 45.8% and 44.4% yield, respectively. The SAMIQ-/RAMIQ-hydrazone methodology was applied for the asymmetric Michael addition of ketones to α,β-unsaturated carboxylic acid methyl esters, which afforded 3-substituted-5-oxo-alkanoates in moderate to good yield (65-82%) with excellent enantioselectivity (ee=95.3%â¼>99.5%).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 70, Issue 31, 5 August 2014, Pages 4602-4610
Journal: Tetrahedron - Volume 70, Issue 31, 5 August 2014, Pages 4602-4610
نویسندگان
Xuan Pan, Zhanzhu Liu,