کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5215878 | 1383246 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Total synthesis of novel bioactive natural product paracaseolide A and analogues: computational evaluation of a 'proposed' biomimetic Diels-Alder reaction
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A short and generally applicable synthesis of bioactive tetracyclic natural product paracaseolide A has been accomplished employing a 'proposed' biomimetic Diels-Alder reaction as the key strategic step. The Diels-Alder precursors for this purpose were readily assembled through a versatile Suzuki coupling on preformed α-halo butenolides. The mechanistic aspects of the 'putative' biomimetic Diels-Alder reaction have been probed using computational methods, which suggest that this [4+2]-cycloaddition proceeds through a step-wise process and product profile is thermodynamically governed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 70, Issue 45, 11 November 2014, Pages 8488-8497
Journal: Tetrahedron - Volume 70, Issue 45, 11 November 2014, Pages 8488-8497
نویسندگان
Laxmaiah Vasamsetty, Debashis Sahu, Bishwajit Ganguly, Faiz Ahmed Khan, Goverdhan Mehta,