Total synthesis of achlisocoumarins I-II from Achlys triphylla

A concise and efficient total synthesis of achlisocoumarin I-II has been completed featuring a construction of the isocoumarin skeleton in a single step and the geranyl coupling with bromoarene ring at −10 °C exclusive of any chelating ligand.

A concise and efficient first total synthesis of achlisocoumarin I-II has been completed featuring a geranyl coupling with bromoarene ring carried out at −10 °C exclusive of any chelating ligand.Figure optionsDownload as PowerPoint slide