Copper catalyzed oxidative cross-coupling of aromatic amines with 2-pyrrolidinone: a facile synthesis of N-aryl-γ-amino-γ-lactams

Synthesis of N-aryl-γ-amino-γ-lactams by oxidative coupling of aromatic amines with 2-pyrrolidinone using catalytic amount of CuO nanoparticles is described. The procedure has broad substrate scope, good yields, complete regioselectivity and catalyst recyclability.

202The oxidative coupling of aromatic amines with 2-pyrrolidinone/NMP affords N-aryl-γ-amino-γ-lactams.