کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5216477 | 1383266 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of gemini surfactants with twelve symmetric fluorine atoms and one singlet 19F MR signal as novel 19F MRI agents Synthesis of gemini surfactants with twelve symmetric fluorine atoms and one singlet 19F MR signal as novel 19F MRI agents](/preview/png/5216477.png)
A family of fluorinated gemini surfactants derived from perfluoropinacol has been synthesized as novel 19F magnetic resonance imaging (19F MRI) agents. These fluorinated surfactants with 12 symmetric fluorine atoms and one singlet 19F MR peak can be conveniently prepared from perfluoropinacol and oligo(ethylene glycols) on multi-gram scales. Solubility, hydrophilicity (log P), and critical micelle concentration (CMC) measurements of these fluorinated surfactants indicated that high aqueous solubility can be achieved by introducing oligo(ethylene glycols) with appropriate length into perfluoropinacol, i.e., manipulating the fluorine content (F%). One of these fluorinated surfactants with high aqueous solubility and excellent 19F MR properties has been identified by 19F MRI phantom experiments as a promising 19F MRI agent.
Journal: Tetrahedron - Volume 69, Issue 46, 18 November 2013, Pages 9586-9590