کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5216714 | 1383274 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselective total synthesis of cananginones (D-I) using Ireland-Claisen rearrangement as a key step
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stereoselective total synthesis of cananginones (D-I) using Ireland-Claisen rearrangement as a key step Stereoselective total synthesis of cananginones (D-I) using Ireland-Claisen rearrangement as a key step](/preview/png/5216714.png)
چکیده انگلیسی
A strategy for stereoselective total synthesis of α-substituted γ-hydroxymethyl γ-butyrolactone containing bioactive natural products cananginones (D-I) has been developed using cheap and commercially available d-mannitol as a chiral pool. The Ireland-Claisen rearrangement is utilized as a key step to generate the α-substituted chiral center of the core lactone moiety, while the elongation of aliphatic side chain by different C-8 hydrocarbon groups have been achieved by alkylation, Cadiot-Chodkiewicz, and Sonogashira reactions.
First stereoselective total synthesis of cananginones (D-I) has been accomplished using Ireland-Claisen rearrangement as a key step.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 70, Issue 18, 6 May 2014, Pages 2905-2918
Journal: Tetrahedron - Volume 70, Issue 18, 6 May 2014, Pages 2905-2918
نویسندگان
Tapan Kumar Kuilya, Shamba Chatterjee, Rajib Kumar Goswami,