Fluorinated NH-iminophosphonates and iminocarboxylates: novel synthons for the preparation of biorelevant α-aminophosphonates and carboxylates

A convenient synthetic approach to previously unknown N-H α-iminophosphonates and iminotrifluoropropionates was developed. The synthetic potential of N-H iminophosphonates and iminotrifluoropropionates, existing as an equilibrium mixture of E/Z-isomers, was demonstrated by their easy functionalization to afford biorelevant fluorinated α-aminophosphonic and α-aminocarboxylic acid derivatives.