کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5216928 1383280 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A C–H oxidation approach for streamlining synthesis of chiral polyoxygenated motifs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A C–H oxidation approach for streamlining synthesis of chiral polyoxygenated motifs
چکیده انگلیسی

Chiral oxygenated molecules are pervasive in natural products and medicinal agents; however, their chemical syntheses often necessitate numerous, wasteful steps involving functional group and oxidation state manipulations. Herein a strategy for synthesizing a readily diversifiable class of chiral building blocks, allylic alcohols, through sequential asymmetric C–H activation/resolution is evaluated against the state-of-the-art. The C–H oxidation routes' capacity to strategically introduce oxygen into a sequence and thereby minimize non-productive manipulations is demonstrated to effect significant decreases in overall step-count and increases in yield and synthetic flexibility.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 36, 9 September 2013, Pages 7771–7778