Ag(I)-catalyzed C–H borylation of terminal alkynes

An efficient Ag(I)-catalyzed borylation method of terminal alkynes is reported. The obtained borylated alkynes are shown to engage in C–Br, C–CN, C–N, and C–C bond formation with various reaction partners. Meanwhile the Ag(I) catalyst could be regenerated in the presence of PPh3 and BF3.

A convenient approach to prepare functionalized pinacol boronate esters was developed by Ag(I)-catalyzed borylation of terminal alkynes using B(OiPr)pin as boron source in the presence of N-heterocyclic carbenes (NHCs) and PPh3. The obtained borylated alkynes are shown to engage in C–Br, C–CN, C–N, and C–C bond formation with various reaction partners.Figure optionsDownload as PowerPoint slide