Design of C2-symmetric salen ligands and their Co(II)- or Yb(III)-complexes, and their role in the reversal of enantioselectivity in the asymmetric Henry reaction

Reversal of enantioselectivity in asymmetric Henry reactions was achieved with novel chiral C2-symmetric salen ligands bearing morpholine moieties by changing the Lewis acid center from Co(II) to Yb(III). The possible transition state models were supported by mass spectrometry experiments.

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