Synthesis of α-galactosyl ceramide analogues with an α-triazole at the anomeric carbon

The synthesis of 1,2,3-triazole containing analogues of α-GalCer and galacturonic acid containing Sphingomonous cell wall antigens is described. Anomerisation was used to provide the required α-glycosyl azide precursor. Copper azide-alkyne cycloaddition (CuAAC) generated the α-triazole linkage.