کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5217515 1383298 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of bis-tetrahydrofuran subunit of (−)-neopallavicinin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of bis-tetrahydrofuran subunit of (−)-neopallavicinin
چکیده انگلیسی

The stereospecific Pd/Cu-catalysed oxycarbonylation of syn/anti-hex-5-ene-2,4-diols 7/8 was used as a key step in the synthesis of bicyclic lactones 5 and 6. Eventually, the major intermediate 5 was transformed to the bis-tetrahydrofuran subunit of naturally occurring diterpenoid (−)-neopallavicinin 2. The target compound 3E was thus prepared in 7.5% overall yield over eight steps starting from commercially available (R)-methyl-3-hydroxybutanoate 9.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 21, 27 May 2013, Pages 4185-4189
نویسندگان
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