Convenient synthesis of perfluoroalkyl substituted 2-oxopyridine-fused 1,3-diazaheterocycles via a one-pot three-component reaction

An efficient one-pot synthesis of perfluoroalkylated ring-fused 2-pyridones by three-component reaction of diamine, ketene dithioacetal, and methyl 2-perfluoroalkynoate in EtOH is reported. This protocol has the advantages of easiness, higher yields, and shorter reaction time. A plausible mechanism for this type of cyclization is proposed.

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