Coumarin-based novel fluorescent zinc ion probe in aqueous solution

A novel coumarin-derived fluorescent probe, FCP, was designed for Zn2+ quantification based on the photo-induced electron transfer (PET) mechanism. This probe selectively and sensitively detects Zn2+ in aqueous solution with wide pH range. Large fluorescence enhancement (13-fold) was observed upon the addition of Zn2+. FCP also displays excellent cell permeability in HeLa cell model and very low cytotoxicity to HEK-293 cell model.

A novel water-soluble Zn2+ fluorescent probe, FCP, was designed by hybrid coumarin and di-2-picolylamine. FCP displayed excellent cell permeability in HeLa cell model and very low cytotoxicity to HEK-293 cells.Figure optionsDownload as PowerPoint slide