Palladium-catalyzed direct ortho-acylation through an oxidative coupling of 2-arylbenzothiazoles with benzylic alcohols

An efficient protocol was developed for Pd-catalyzed direct C-H bond acylation by cross-dehydrogenative-coupling of arylbenzothiazoles and benzylic alcohols using tert-butyl hydroperoxide (TBHP) as the oxidant. The acylation reactions exhibit good reactivities and excellent regioselectivity.