کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5217865 | 1383309 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents](/preview/png/5217865.png)
چکیده انگلیسی
A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with good yields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-one system was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda and one of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generally at low micromolar concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 31, 5 August 2013, Pages 6474-6477
Journal: Tetrahedron - Volume 69, Issue 31, 5 August 2013, Pages 6474-6477
نویسندگان
Paola Barraja, Virginia Spanò, Daniele Giallombardo, Patrizia Diana, Alessandra Montalbano, Anna Carbone, Barbara Parrino, Girolamo Cirrincione,