Stereoselective synthesis of a C1−C18 fragment of amphidinolides G and H

A stereoselective synthesis of a C1-C18 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. The target compound was retrosynthetically disconnected into three fragments. In the synthetic sense, connection of the fragments was made by means of a Stille coupling and a Julia-Kocienski olefination. Precursors from the chiral pool were used as the starting materials.