Senedensiscins A–F: six new eudesmane sesquiterpenoid glucosides from Senecio densiserratus

Six new highly oxygenated eudesmane sesquiterpenoid glucosides, senedensiscins A–F (1–6), were isolated from the aerial parts of Senecio densiserratus. Their structures with the absolute configurations were established on the basis of spectroscopic analyses and chemical methods. These compounds represent an unprecedented type of sesquiterpenoid glucoside with the angeloyl group directly connected to the glucosyl moiety and their cytotoxicity was evaluated against the selected human cell lines, HL-60, SMMC-7721, and HeLa.

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