کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5218049 | 1383314 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nine new lycopodine-type alkaloids from Lycopodium japonicum Thunb.
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nine new alkaloids (1-9) with lycopodine-related structures, i.e., 6α,8β-dihydroxylycopodine, 4α,8β-dihydroxylycopodine, alongside thirteen known compounds (10-22), were isolated from the club moss Lycopodium japonicum Thunb. The structures of the new alkaloids including their absolute configurations were elucidated by extensive spectroscopic analysis, CD method, and by comparison with known analogs. Six of the alkaloids isolated displayed moderate activities against lipopolysaccharide (LPS)-induced pro-inflammatory factors in BV2 macrophages with IC50 values of 4.23-49.03 μM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 30, 29 July 2013, Pages 6234-6240
Journal: Tetrahedron - Volume 69, Issue 30, 29 July 2013, Pages 6234-6240
نویسندگان
Xiao-Jing Wang, Li Li, Yi-Kang Si, Shi-Shan Yu, Shuang-Gang Ma, Xiu-Qi Bao, Dan Zhang, Jing Qu, Yun-Bao Liu, Yong Li,