کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5218131 1383317 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel multicomponent reaction involving isoquinoline, allenoate and activated ketone
ترجمه فارسی عنوان
یک واکنش چند ترکیب چندگانه شامل ایزوینولین، آلنئات و کتون فعال شده است
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

The reaction of isoquinoline and allenoate with activated ketone resulted in a novel three component reaction, affording [1,3]oxazino[2,3-a]isoquinoline derivatives in moderate yields along with moderate diastereoselectivities via 1,4-dipolar cycloaddition. It was also found that when isatins were used as substrates, the regioselectivity of cycloadducts was different from those using ethyl trifluoropyruvate as substrate.

1,4-Dipole, generated in situ from isoquinoline with allenoate, reacts with activated ketone to afford [1,3]oxazino[2,3-a]isoquinoline derivatives in moderate yields along with moderate diastereoselectivities. This reaction enriches the chemistry of zwitterion formed from nitrogen nucleophile and electron-deficient alkyne.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 44, 4 November 2013, Pages 9205–9211