Generation of 1-aroxyisoquinolines via a silver-catalyzed reaction of 2-alkynylbenzaldoxime with phenol in the presence of p-toluenesulfonyl chloride

A silver-catalyzed reaction of 2-alkynylbenzaldoxime with phenol promoted by p-toluenesulfonyl chloride leads to 1-aroxyisoquinolines in good yields. The presence of p-toluenesulfonyl chloride as an activator is essential for the successful transformation.

Figure optionsDownload as PowerPoint slide