کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5218290 | 1383322 | 2013 | 7 صفحه PDF | دانلود رایگان |
Two routes for the synthesis of homofascaplysin B, C and analogues have been established using the photocyclization as the key step. The first route is based on sequential photocyclization and photochemical dehydrogenation reactions of 2-chloro-3-acyl-1-[2-(indol-3-yl)ethyl]indoles in Cu(OAc)2- and air-saturated acetone; and the second is based on the two-step reactions, namely, photocyclization of 2-chloro-3-acyl-1-[2-(indol-3-yl)ethyl]indoles in acetone and DDQ-mediated dehydrogenation of 13-acyl-6,7-dihydro-pyrido[1,2-a;3,4-b′]diindoles in benzene at room temperature. Comparatively, the two-step route for the synthesis of homofascaplysin B, C and analogues is more efficient than the one-pot route.
Figure optionsDownload as PowerPoint slide
Journal: Tetrahedron - Volume 69, Issue 7, 18 February 2013, Pages 1912–1918