کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5218341 1383324 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Catalytic Lewis acid phosphorylation with pyrophosphates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Catalytic Lewis acid phosphorylation with pyrophosphates
چکیده انگلیسی

We report a method for the Lewis acid catalyzed phosphorylation of alcohols with pyrophosphates. Ti(OtBu)4 was found to be the most effective catalyst in the phosphorylation of both primary and secondary alcohols with tetrabenzylpyrophosphate, providing conversions between 54% and >98% and isolated yields between 50% and 97%. Other pyrophosphates with orthogonal protecting groups were synthesized and screened to validate the generality of the approach. This study will describe how benzyl, methyl, ethyl, allyl, and o-nitrobenzyl pyrophosphates are all effective phosphorylating agents under Lewis acid catalysis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 44, 4 November 2012, Pages 9023-9028
نویسندگان
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