کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5218380 | 1383326 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of the C1-C8 subunit of peloruside A
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Two routes to the C1-C8 subunit of peloruside A are disclosed. The first route involving 14 steps exploits Krische's allylation, substrate controlled 1,3-asymmetric induction during bromohydrin formation from an alkene utilizing an intramolecular sulfinyl group as a nucleophile and Pummerer reaction as key steps. The second, shorter, scalable route (seven steps) exploits catalytic asymmetric reactions including Jacobsen's hydrolytic kinetic resolution of an epoxide and Sharpless' asymmetric dihydroxylation reaction as the key steps.
Two routes to the stereoselective synthesis of the C1-C8 subunit of peloruside A is disclosed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 24, 17 June 2013, Pages 4835-4844
Journal: Tetrahedron - Volume 69, Issue 24, 17 June 2013, Pages 4835-4844
نویسندگان
Sadagopan Raghavan, V. Vinoth Kumar,