کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5218532 | 1383330 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Organocatalytic Michael addition of aldehydes to trisubstituted nitroolefins
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Organocatalytic Michael addition of aldehydes to trisubstituted nitroolefins Organocatalytic Michael addition of aldehydes to trisubstituted nitroolefins](/preview/png/5218532.png)
چکیده انگلیسی
The combination of O-TMS protected diphenyl-prolinol and benzoic acid was found to be effective to catalyze the Michael addition of aldehydes to 3-substituted 3-nitroacrylates. The reaction provided syn,anti-Michael adducts with good diastereoselectivity and excellent enantioselectivity. Some β-aryl and α-methyl substituted nitroolefins also worked under these conditions, although prolonging reaction time was required. These adducts could be used for assembling 2,3,4-trisubstituted pyrrolidines through simple hydrogenation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 37, 16 September 2012, Pages 7675-7679
Journal: Tetrahedron - Volume 68, Issue 37, 16 September 2012, Pages 7675-7679
نویسندگان
Leilei Wang, Xiaojing Zhang, Dawei Ma,