New synthesis and reactions of indolizidine 167E and indolizidine derivatives

Two new methods of synthesizing indolizidines via ring-closing metathesis (RCM) have been developed. One method utilizes an alkene-isomerization, and the other method uses N-vinylation of an amide as the key step. Indolizidine 167E and many derivatives have also been synthesized.

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