کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5218612 1383332 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Palladium-catalyzed ortho-acylation of 2-arylbenzoxazoles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Palladium-catalyzed ortho-acylation of 2-arylbenzoxazoles
چکیده انگلیسی

An efficient and facile catalytic protocol for benzoxazole-directed ortho-acylation of 2-arylbenzoxazoles has been described using aldehydes as the easily accessible acyl source. This catalytic system was performed in the presence of tert-butyl hydroperoxide (TBHP) as the oxidant in chlorobenzene, affording the acylated 2-arylbenzoxazoles in moderate to good yields. The acylation exhibited high regioselectivity for the substrates containing a meta-substituent in the benzene ring and typically occurred at the less sterically hindered ortho-C–H bond of the directing group.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 1, 7 January 2013, Pages 320–326