An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate

A facile and efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of readily available alkynyl aldehydes, amines, and ethyl 2-((diphenylmethylene)amino)acetate has been developed. The alkynyl aldehyde substrates and the amine partners can be flexibly varied to achieve a range of 3-amino-2-pyridone derivatives, which could exert interesting chemical and biological properties. The reaction mechanism for the formation of 3-amino-2-pyridone derivatives is briefly explained.