Regioselective lateral or vinyl C–H lithiation/1,5-retro-Brook rearrangement via quinolyl or pyridyl ring directed deprotonation

A regioselective lateral or vinyl C–H lithiation/1,5-retro-Brook rearrangement via quinolyl or pyridyl ring directed deprotonation has been developed. 16 examples were tested and the corresponding alkyl silanes and E-vinyl silanes were obtained in moderate to good yields.

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