Chemical resolution and chiral recognition of an inherently chiral biscalix[4]arene cone-partial cone conformer

An inherently chiral biscalix[4]arene carboxylic acid cone-partial cone conformer was optically resolved into individual enantiomers by chemical resolution method using (S)-BINOL as a chiral auxiliary. The partial cone calix[4]arene component plays a crucial role in optical resolution. The title compound may interact enantiodiscriminantly with chiral aminoalcohols, especially 2-phenylglycinol.