کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5218912 | 1383341 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diastereospecific fluorination of substituted azepanes
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, there is no report on fluorination of azepanes. As azepanes are components of many biologically active substances and natural products. We herein present the first fluorination examples of substituted azepanes. Fluoroazepanes were prepared by deoxyfluorination diastereospecifically in excellent yields. The absolute configuration at the fluorination site was unambiguously assigned by 2D NMR spectroscopy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 2, 14 January 2013, Pages 744-752
Journal: Tetrahedron - Volume 69, Issue 2, 14 January 2013, Pages 744-752
نویسندگان
Alpesh Ramanlal Patel, Fei Liu,