Total synthesis of sapinofuranone A from d-ribose

The total synthesis of sapinofuranone A has been achieved starting from naturally occurring carbohydrate d-ribose via a short and high yielding route. The key transformations include Wittig olefination, Ohira-Bestmann reaction, Sonogashira coupling. Finally acetonide deprotection and subsequent lactonization using catalytic amount of hydrochloric acid completed the total synthesis of sapinofuranone A.