کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5219098 | 1383347 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An investigation on stereospecific fluorination at the 2â²-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2â²-deoxy-2â²-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An investigation on stereospecific fluorination at the 2â²-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2â²-deoxy-2â²-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil An investigation on stereospecific fluorination at the 2â²-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2â²-deoxy-2â²-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil](/preview/png/5219098.png)
چکیده انگلیسی
Direct fluorination at the 2â²-arabino-position of a pyrimidine nucleoside has been a long-standing challenge, yet we recently reported such a stereospecific fluorination for the first time in the synthesis of [18F]FMAU, albeit in low yields. Herein we report the results of an investigation on stereospecific fluorination on a variety of precursors for synthesis of [18F]FMAU. Several precursors were synthesized in multiple steps and fluorination was performed at the 2â²-arabino-position using K[18F]/kryptofix 2.2.2. All precursors produced [18F]FMAU in low yields.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 50, 16 December 2012, Pages 10326-10332
Journal: Tetrahedron - Volume 68, Issue 50, 16 December 2012, Pages 10326-10332
نویسندگان
Nashaat Turkman, Vincenzo Paolillo, Juri G. Gelovani, Mian M. Alauddin,