کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5219296 1383352 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 12-epi-ent-polyalthenol an antitumour indole sesquiterpene alkaloid
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 12-epi-ent-polyalthenol an antitumour indole sesquiterpene alkaloid
چکیده انگلیسی

The synthesis of 12-epi-ent-polyalthenol, 10, and its epimer at C-19, 11, from ent-halimic acid as starting material has been carried out. The structure of the natural product polyalthenol 1 is confirmed in this way. The synthesized indole sesquiterpenes 10 and 11 and their acetylderivatives 32 and 33 inhibited cellular proliferation of a number of human leukaemic and solid tumour cell lines.

12-Epi-ent-polyalthenol has been synthesized from ent-halimic acid. The indole sesquiterpenes synthesized inhibit proliferation of several human tumour cells, including leukemic and solid tumour cells, with an IC50 in the range of 25 μM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 38, 23 September 2012, Pages 7932-7940
نویسندگان
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