Morita–Baylis–Hillman reactions of isatins with allenoates

4-(N,N-dimethylamino)pyridine (DMAP) was found to be a fairly efficient catalyst for the Morita–Baylis–Hillman reactions of isatins with α-substituted allenoates to give the corresponding products in good to high yields with moderate diastereoselectivities under mild conditions.

4-(N,N-dimethylamino)pyridine (DMAP)-catalyzed Morita–Baylis–Hillman (MBH) reaction of isatins with α-substituted allenoates has been investigated. This reaction can afford the corresponding MBH products in good to high yields with moderate diastereoselectivities under mild conditions.Figure optionsDownload as PowerPoint slide