کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5219608 1383362 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of the intramolecular PIFA-mediated amidation of alkynes to the synthesis of substituted indolizidinones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Application of the intramolecular PIFA-mediated amidation of alkynes to the synthesis of substituted indolizidinones
چکیده انگلیسی

The construction of the title compounds has been achieved from properly substituted linear alkynylamides through the suitable combination of two key cyclization steps. First, an intramolecular PIFA-mediated alkyne amidation protocol leads to the creation of the pyrrolidinone nucleus, which under proper manipulation of the generated keto-carbonyl group permits the assembling of the indolizidinone skeleton by the introduction of a subsequent ring closing olefin metathesis step. Finally, its transformation into a series of substituted mono- and trihydroxylated indolizidinone derivatives is achieved by manipulation of the remaining unsaturated fragment under hydrogenation and dihydroxylation conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 19, 13 May 2012, Pages 3692-3700
نویسندگان
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