Domino cyclocondensation of arylaldehydes with 2-acetylpyridine

A novel synthetic route for the preparation of cyclohexane skeleton 3 was developed via the one-pot domino Claisen–Schmidt condensation reaction/Michael addition/double aldol reaction of 1 equiv of functionalized arylaldehyde 1 with 3 equiv of 2-acetylpyridine (2a).

Figure optionsDownload as PowerPoint slide