I-MCR-Ullmann cascade toward furo[2,3-b]indole scaffold

An efficient method for the construction of furo[2,3-b]indole derivatives 5 via an isocyanide-based multicomponent reaction (I-MCR) and a copper-catalyzed intramolecular Ullmann reaction sequence was described. This two-step sequence can be performed in a one-pot manner to produce the desired product 5 in moderate to good yield (up to 90%).

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