کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5220329 | 1383384 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biosynthetic pathway of macrolactam polyketide antibiotic cremimycin
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Biosynthetic origin of macrolactam polyketide antibiotic cremimycin was investigated by feeding experiments with [1-13C]acetate, [1,2-13C2]acetate, [1-13C]propionate, succinate-d4, and d-[6,6-2H2]glucose. NMR analysis of the resultant isotope-enriched cremimycins showed distinctive incorporation patterns, which suggested that the aglycon of cremimycin was constructed from two propionates and eleven acetates. Thus, 3-oxononanoate was proposed as a potential polyketide intermediate, that is, aminated to be the unique nitrogen-containing moiety of cremymicin. Further, characteristic propionate biosynthetic pathway in the cremimycin-producing strain was also described.
Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 44, 4 November 2011, Pages 8559–8563
Journal: Tetrahedron - Volume 67, Issue 44, 4 November 2011, Pages 8559–8563