کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5220411 1383387 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Syntheses of aza-analogues of macrosphelides via RCM strategy and their biological evaluation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Syntheses of aza-analogues of macrosphelides via RCM strategy and their biological evaluation
چکیده انگلیسی

Syntheses of 16-membered macrolactams, which were aza-analogues of macrosphelides, could be established effectively by a ring-closing metathesis (RCM) strategy. Novel 19 analogues and six aza-macrosphelide-epothilone hybrids were furnished according to simple operations. Biological assay of these artificial aza-macrosphelides revealed that some of them showed stronger apoptosis-inducing activity against human lymphoma cells than the parent compound.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 40, 7 October 2011, Pages 7681-7685
نویسندگان
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