کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5220547 | 1383391 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b](/preview/png/5220547.png)
چکیده انگلیسی
An enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b has been achieved by a convergent protocol, which was featured by an enantioselective organocatalytic transfer hydrogenation of enal, a Julia-Kocienski olefination to establish the C15-C16 E-olefin moiety, a Kulinkovich reaction associated with cyclopropyl-allyl rearrangement to produce allyl stannane and ytterbium triflate and carboxylic acid promoted allylation between allyl stannane and aldehyde with tertiary alcohol at the α-position. The construction of macrolide 2 was realized by the successful implementation of RCM utilizing 5 mol % Grubbs's second generation catalyst at room temperature with E-isomer as a single product.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 33, 19 August 2011, Pages 5979-5989
Journal: Tetrahedron - Volume 67, Issue 33, 19 August 2011, Pages 5979-5989
نویسندگان
Zhengqing Ye, Tingyi Gao, Gang Zhao,