کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5220717 | 1383397 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
l-Isofucoselenofagomine and derivatives: dual activities as antioxidants and as glycosidase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The synthesis of a series of l-fuco-configured selenosugars, isosters of the potent glycosidase inhibitor isofucofagomine has been accomplished by a double nucleophilic displacement of a dimesylated derivative with selenide anion generated in situ. Se-Alkylation and oxidation of the corresponding selenane afforded a selenonium and a selenoxide, respectively. The biological activities of such compounds have been evaluated, finding a dual activity caused by the presence of the selenium atom: the selenane exerted a good glutathione peroxidase mimicry by efficiently scavenging H2O2 in the presence of thiols, whereas the stable selenoxide derivative was found to be the first example of a selenosugar acting as a good α-l-fucosidase inhibitor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 18, 6 May 2012, Pages 3591-3595
Journal: Tetrahedron - Volume 68, Issue 18, 6 May 2012, Pages 3591-3595
نویسندگان
Penélope Merino-Montiel, Ãscar López, José G. Fernández-Bolaños,