Biverlactones A–D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429

Biverlactones, new circumventors of arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA) were isolated from a culture broth of Penicillium sp. FKI-4429. Their structures were elucidated by spectroscopic studies, including various NMR experiments. Biverlactones A–D had novel skeletons, consisting of a lactone ring conjugated with exo- or endo-olefin, a carboxylic group and a characteristic alkyl side chain in common.

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