The galbulimima alkaloids-a new frontier in alkaloid synthesis

The immense synthetic challenges posed by the galbulimima alkaloids have recently been overcome by the innovative application of powerful classical methods, such as the Diels-Alder reaction, Michael addition, aldol condensation, and radical cyclization, supplemented by the invention of new reactions. These achievements are analyzed according to the different ways of assembling the various substructural ring systems.