کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5220861 | 1383401 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
XY-ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The results of the reaction of aminomethyl heterocycles and 4,6-dimethyl-2-formylpyrimidine and of activated secondary amines with different aryl/heteroaryl or aliphatic aldehydes and N-methylmaleimide or maleimide are described. In the former case the reactions gave single diastereomers via endo-transition states whilst the latter gave a mixture of diastereomers, which are believed to arise from anti-dipoles via endo/exo transition states. The stereochemistry of the cycloadducts was determined by 1H NMR and confirmed by X-ray crystallography.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 31, 5 August 2011, Pages 5700-5710
Journal: Tetrahedron - Volume 67, Issue 31, 5 August 2011, Pages 5700-5710
نویسندگان
Elghareeb E. Elboray, Ronald Grigg, Colin W.G. Fishwick, Colin Kilner, Mohammed A.B. Sarker, Moustafa F. Aly, Hussien H. Abbas-Temirek,