کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5221435 1383420 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sequencing cross-metathesis and non-metathesis reactions to rapidly access building blocks for synthesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Sequencing cross-metathesis and non-metathesis reactions to rapidly access building blocks for synthesis
چکیده انگلیسی

The olefin cross-metathesis reaction has been sequenced with four common organic transformations in a one- or two-pot manner to rapidly access useful building blocks. Those reactions are: (1) phosphorus-based olefination (e.g., Wittig and Horner-Wadsworth-Emmons); (2) hydride reduction; (3) Evans propionate aldol reaction; (4) Brown allyl- and Roush crotyl-boration. The products of these reactions include stereodefined 2,4-dienoates, trans allylic alcohols, syn-propionate aldols, and chiral non-racemic homoallylic alcohols, respectively. Many of these intermediates have been carried further to natural products, demonstrating the utility of the methodology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 12, 25 March 2011, Pages 2197-2205
نویسندگان
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